Ayele H. Negussie

National Institutes of Health Clinical Center, National Institutes of Health

Papers

Total Citations

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About

Ayele H. Negussie is a biomedical engineer whose research centers on the development of magnetic resonance imaging (MRI)-guided robotic systems for targeted cancer interventions, with a primary focus on prostate cancer. His major contributions lie in the design and validation of novel, MR-compatible robots that enable precise, in-gantry focal laser ablation—a minimally invasive alternative to radical treatments like prostatectomy. Negussie’s work addresses the critical need for high-accuracy needle placement within the confined lithotomy space of an MRI bore, replacing traditional grid templates with autonomous, high-resolution positioning systems. His most-cited paper, “MRI Robot for Prostate Focal Laser Ablation: An Ex Vivo Study in Human Prostate” (2018, 11 citations), demonstrates the clinical potential of his robotic platform through ex vivo validation. Complementary studies, including a phantom-based evaluation (2019, 4 citations) and an earlier design iteration (2016, 5 citations), collectively establish a trajectory toward improved patient outcomes by reducing side effects like impotence and incontinence. Negussie’s work is foundational for advancing precision oncology, bridging robotics and imaging to transform prostate cancer care.