Dylan Yatigammana

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Dylan Yatigammana is a pioneer in noninvasive functional imaging, whose work has fundamentally reshaped how we study brain activity in awake, unrestrained animals. His key research areas span motion-compensated positron emission tomography (PET), behavioral neuroscience, and advanced tracking methodologies. Yatigammana’s landmark contribution, the development of markerless motion tracking for awake animals in PET, eliminated the need for anesthetics during imaging—a critical advance that allows researchers to observe an animal’s natural behavioral responses to stimuli or administered drugs in real time, concurrent with radiotracer uptake. His seminal 2014 paper on this technique has garnered 49 citations, establishing a foundational framework for motion-compensated neuroimaging. This work not only enhances the translational relevance of preclinical studies but also opens new avenues for investigating the neural correlates of behavior and drug effects. Yatigammana’s innovative approach has been widely adopted, influencing subsequent designs for motion-tracking systems in small-animal imaging. His achievements underscore a commitment to refining experimental paradigms, making him a notable figure in the intersection of biomedical engineering and behavioral neuroscience.