Denis Malyshev
Papers
2
Total Citations
145
H-Index
2
About
Denis Malyshev is a pioneering translational researcher in personalized oncology, specializing in rare and difficult-to-treat cancers. His work centers on developing innovative, patient-specific drug screening platforms using model organisms to identify effective therapies where standard treatments fail. Malyshev’s major contributions include the creation of a personalized platform employing Drosophila (fruit flies) to rapidly test drug combinations. In a landmark 2019 study (107 citations), his team used this platform to identify trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer, achieving a strong partial response that remained stable for 11 months. He further demonstrated the platform’s power in a 2021 study (38 citations) by discovering a novel therapy for adenoid cystic carcinoma, a rare salivary gland cancer with limited treatment options. Malyshev’s work is notable for bridging preclinical models directly to clinical application, offering hope for patients with genetically complex or orphan cancers. His highly cited research underscores the impact of personalized, robotics-based screening in transforming cancer care.
Research Focus
Key Achievements
Top Papers
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