Tiina Jokela
Papers
1
Total Citations
25
H-Index
1
About
Tiina Jokela is a leading cancer biologist whose research focuses on the critical role of the tumor microenvironment in driving epithelial plasticity and therapy resistance. Her most-cited work, a 2018 study with 25 citations, provides compelling evidence that specific microenvironments can impose non-sporadic, or collective, expression of key proteins like AXL and cKIT. This groundbreaking finding challenges the prevailing model that drug tolerance arises only from rare, sporadic cancer cells, revealing instead that the surrounding tissue can actively orchestrate a widespread, epigenetic shift toward a drug-resistant state. By linking microenvironmental cues directly to the expression of these clinically significant receptors, Jokela’s research illuminates a powerful mechanism of therapy failure. Her work has profound implications for understanding how tumors adapt and evade treatment, paving the way for novel therapeutic strategies that target not just the cancer cell, but the entire ecosystem that supports its resilience.
Research Focus
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Top Papers
- 1