Masaru Miyano
Papers
1
Total Citations
25
H-Index
1
About
Dr. Masaru Miyano is a pioneering cancer biologist whose research illuminates the critical role of the tumor microenvironment in driving drug resistance and epithelial plasticity. His landmark 2018 study, cited 25 times, fundamentally challenged the prevailing "sporadic" model of drug-tolerant cancer cells by demonstrating that specific microenvironments can impose non-sporadic, coordinated expression of AXL and cKIT receptors. This work revealed that rather than being random, these resistance mechanisms can be systematically induced by surrounding tissue conditions, offering a new framework for understanding therapy failure. Dr. Miyano's contributions have profound implications for developing combination therapies that target both cancer cells and their protective niches. By showing that microenvironmental cues actively orchestrate epithelial plasticity and drug tolerance, his research provides a mechanistic basis for why some tumors relapse despite initial treatment success. His findings continue to influence how researchers approach the challenge of cancer persistence, making him a key voice in the field of tumor biology and therapeutic resistance.
Research Focus
Key Achievements
Top Papers
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