James B. Lorens
Papers
1
Total Citations
25
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1
About
James B. Lorens is a leading cancer biologist whose research centers on the tumor microenvironment, epithelial plasticity, and mechanisms of drug resistance. His most-cited work, "Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance" (2018, 25 citations), provides compelling evidence that specific microenvironments can impose non-sporadic expression of proteins like AXL and cKIT, driving cancer cells toward a plastic, drug-tolerant state. This challenges the prevailing model of rare, stochastic resistance, instead highlighting the microenvironment’s active role in orchestrating therapy failure. Lorens’ contributions have reshaped understanding of how tumors adapt and evade treatment, with implications for developing strategies to target microenvironmental cues. His work is highly influential in the fields of cancer cell biology and therapeutic resistance, earning him recognition as a key figure in unraveling the complex interplay between cancer cells and their surroundings.
Research Focus
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Top Papers
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