Luca Mattei

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About

Luca Mattei is a neurosurgeon and researcher specializing in stereotactic neurosurgery and the clinical translation of robotic technologies. His primary research focuses on the development and validation of image-guided robotic systems for minimally invasive intracranial procedures. Mattei’s most notable contribution is his prospective pilot study evaluating the iSYS1, a small robotic device for image-guided biopsy of deep-seated or inoperable intracranial lesions. This work, published in 2019 and cited 24 times, demonstrated the feasibility and safety of a compact robotic platform in the neurosurgical operating room, offering a less invasive alternative to traditional frame-based or freehand stereotactic biopsies. By systematically assessing the device’s accuracy and clinical outcomes, Mattei provided early evidence supporting the integration of robotic assistance into routine neurosurgical practice. His research addresses a critical need for precision in targeting small or eloquent brain lesions, potentially reducing patient morbidity. Mattei’s work bridges engineering and clinical neurosurgery, contributing to the growing field of robotic stereotaxy and advancing the standard of care for patients requiring diagnostic tissue sampling.