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About

Federico Legnani is a pioneering neurosurgeon whose work centers on advancing minimally invasive neurosurgical techniques, particularly through the integration of robotic systems and thermal therapies. His major contributions lie in the development and validation of robot-guided stereotactic procedures for brain tumor biopsies and treatments. His most cited paper (36 citations) introduces a novel robot-guided technique that overcomes the accuracy and usability limitations of traditional frame-based and frameless biopsy methods, addressing the growing need for precise tissue sampling driven by molecular pathology. In a prospective pilot study (24 citations), Legnani demonstrated the clinical feasibility and safety of the iSYS1 robotic device for image-guided intracranial biopsies, marking a significant step toward routine robotic assistance in neurosurgery. He further expanded this technology’s application by combining the iSYS1 robot with laser-interstitial thermal therapy (LITT) using the Visualase system, detailing a reproducible workflow for minimally invasive tumor ablation. With a clear focus on translating engineering innovations into practical surgical solutions, Legnani’s work has directly improved the precision, safety, and accessibility of stereotactic neurosurgery, earning him recognition as a key figure in the robotic neurosurgery field.