Jing-Qing Luo
Papers
1
Total Citations
8
H-Index
1
About
Jing-Qing Luo has made significant contributions to the field of G protein-coupled receptor (GPCR) pharmacology, with a particular focus on adenosine receptor signaling and high-throughput screening (HTS) assay development. Their most cited work centers on the functional analysis of the human adenosine A2a receptor, a key therapeutic target implicated in neurological disorders, inflammation, and cancer. Luo developed a sensitive and HTS-compatible reporter gene assay in CHO-K1 cells, enabling robust detection of receptor activation through the stimulatory G protein-adenylate cyclase pathway. This methodological innovation, published in 2004, has garnered 8 citations and provided a critical tool for drug discovery efforts targeting A2a receptors. By establishing a stable transfection system and optimizing assay conditions for compatibility with automated screening platforms, Luo’s work bridged fundamental GPCR biology with practical pharmacological applications. Their research exemplifies the integration of molecular pharmacology and assay engineering, offering a reproducible platform for evaluating agonist and antagonist activity. Luo’s contributions continue to support the development of novel therapeutics, underscoring their impact on both academic research and pharmaceutical development.
Research Focus
Key Achievements
Top Papers
- 1