Mary Jo Wildey

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About

Mary Jo Wildey is a distinguished researcher whose work centers on the development of high-throughput screening (HTS) assays and the functional analysis of G protein-coupled receptors (GPCRs), particularly the human adenosine A2a receptor. Her most cited paper, “Development of a Sensitive and HTS-Compatible Reporter Gene Assay for Functional Analysis of Human Adenosine A2a Receptors in CHO-K1 Cells” (2004, 8 citations), represents a key contribution to pharmacological research. In this study, Wildey successfully engineered a stable cell-based assay using Chinese hamster ovary (CHO-K1) cells, enabling sensitive, reproducible, and automation-friendly measurement of A2a receptor activation via the stimulatory G protein-adenylate cyclase pathway. This work provided a critical tool for drug discovery, facilitating the screening of compounds targeting this important GPCR, which is implicated in neurological and cardiovascular diseases. Additionally, her 1999 response on automation basics (“Automation Basics: Robotics vs. Workstations,” 2 citations) reflects her expertise in laboratory automation and assay miniaturization. Wildey’s contributions have advanced the practical application of HTS technologies, bridging molecular pharmacology and industrial drug development. Her work remains a reference for researchers developing cell-based assays for GPCRs, underscoring her impact on the field of assay development and receptor pharmacology.