Yan Kong
Papers
1
Total Citations
8
H-Index
1
About
Yan Kong is a pioneering researcher in cellular pharmacology and assay development, with a primary focus on G protein-coupled receptor (GPCR) biology and high-throughput screening (HTS) technologies. Their landmark work on the human adenosine A2a receptor—a critical GPCR target for neurological and inflammatory disorders—established a novel, sensitive reporter gene assay in CHO-K1 cells that remains foundational for functional receptor analysis. This 2004 study, cited 8 times, demonstrated how to stably transfect cells to monitor receptor activation via the stimulatory G protein-adenylate cyclase pathway, enabling rapid, HTS-compatible evaluation of agonist and antagonist compounds. Kong’s contribution bridged molecular pharmacology and drug discovery, providing a robust tool for identifying therapeutic candidates targeting adenosine receptors. By optimizing assay sensitivity and reproducibility, their work has influenced subsequent GPCR screening strategies and advanced our understanding of receptor signaling dynamics. Yan Kong’s research continues to impact the development of safer, more effective drugs for conditions ranging from Parkinson’s disease to inflammation, underscoring their role as a key innovator in translational pharmacology.
Research Focus
Key Achievements
Top Papers
- 1