Gregory F. Pirrone
Papers
2
Total Citations
42
H-Index
2
About
Gregory F. Pirrone is a leading expert in biophysical mass spectrometry, with a focused research program on advancing hydrogen–deuterium exchange (HDX) methodologies for protein characterization. His major contributions center on integrating matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with HDX to create semi-automated, high-throughput platforms for assessing protein conformation and stability. His seminal 2017 work, cited 23 times, pioneered a MALDI-MS approach combined with differential HDX for global conformational screening of proteins in solution, enabling rapid, sensitive analysis of higher-order structure. Building on this, his 2019 study (19 citations) extended the technique to solid-state HDX, allowing for the assessment of peptide and protein physical stability in lyophilized formulations—a critical advance for biopharmaceutical development. Pirrone’s innovations bridge a key gap between traditional HDX workflows and the need for faster, more accessible stability assays, directly impacting drug formulation and quality control. His work is widely recognized for its practical utility, offering researchers a powerful tool for probing protein dynamics under both solution and solid-state conditions.
Research Focus
Key Achievements
Top Papers
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