Timothy Rhodes
Papers
1
Total Citations
23
H-Index
1
About
Timothy Rhodes is a leading figure in biophysical mass spectrometry, whose work has fundamentally advanced how researchers probe protein structure and dynamics. His primary research focuses on the development and application of hydrogen-deuterium exchange (HDX) mass spectrometry, a powerful technique for studying protein conformation, folding, and interactions. Rhodes’s major contribution lies in pioneering the integration of matrix-assisted laser desorption/ionization (MALDI) with HDX, a breakthrough that enabled semi-automated, high-throughput global conformational screening of proteins. His seminal 2017 paper on this method, which has garnered 23 citations, demonstrated how coupling MALDI with a time-of-flight (TOF) detector could streamline the analysis of biological molecules, making HDX more accessible for routine biophysical characterization. This work has had a tangible impact on the field, providing a robust platform for studying protein higher-order structure and stability. Beyond this, Rhodes is recognized for his efforts to standardize HDX-MS workflows, helping to bridge the gap between specialized mass spectrometry and broader structural biology applications. His contributions continue to shape how scientists investigate protein behavior, with implications for drug discovery and biotherapeutic development.
Research Focus
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Top Papers
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