Nicole Canfield
Papers
2
Total Citations
59
H-Index
2
About
Nicole Canfield’s research sits at the intersection of pharmaceutical science and biophysical chemistry, with a focus on improving the analysis and solubility of therapeutic compounds. Her most influential work tackles a critical bottleneck in drug development: the poor aqueous solubility of many new chemical entities. In her 2017 study, Canfield used a design-of-experiments approach to systematically investigate how the composition of simulated intestinal media affects the solubility of poorly soluble compounds. This work, which has garnered 36 citations, provides a robust, data-driven framework for more accurately predicting in vivo drug behavior during preclinical testing. In a second highly cited paper (23 citations), she advanced protein characterization by combining matrix-assisted laser desorption/ionization (MALDI) mass spectrometry with differential hydrogen-deuterium exchange (HDX). This semiautomated method enables rapid, global conformational screening of proteins, offering a powerful tool for studying protein higher-order structure and stability. By integrating experimental design with cutting-edge mass spectrometry, Canfield’s contributions help bridge the gap between fundamental biophysics and applied pharmaceutical development, making her work valuable for researchers in drug formulation, biotherapeutics, and structural biology.
Research Focus
Key Achievements
Top Papers
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