Papers
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Total Citations
19
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About
Ian Mangion is a leading figure in pharmaceutical analysis and biophysical characterization, whose research focuses on advancing mass spectrometry techniques for assessing the stability of therapeutic proteins and peptides. His most-cited work, "Use of MALDI-MS with solid-state hydrogen deuterium exchange for semi-automated assessment of peptide and protein physical stability in lyophilized solids" (2019, with 19 citations), introduces a groundbreaking semi-automated method that combines matrix-assisted laser desorption/ionization mass spectrometry with solid-state hydrogen-deuterium exchange. This approach enables rapid, high-throughput evaluation of protein physical stability in lyophilized formulations—a critical factor in the development of stable biopharmaceuticals. Mangion’s contributions are particularly impactful for the pharmaceutical industry, where maintaining protein integrity during storage and delivery is paramount. By streamlining stability assessment, his work reduces time and resource demands in drug development, offering a practical tool for researchers and manufacturers. His innovative integration of analytical chemistry with biophysics underscores his role as a pioneer in formulation science, making him a valuable resource for students and professionals seeking to understand the intersection of mass spectrometry and biotherapeutic stability.
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