Daniel Surbek
Papers
1
Total Citations
8
H-Index
1
About
Daniel Surbek is a leading figure in structural biology, specializing in the molecular architecture of ion channels and membrane proteins. His research focuses on elucidating the three-dimensional structures of these critical proteins, particularly transient receptor potential (TRP) channels, to understand their function and regulation at the atomic level. A landmark contribution is his work on human TRPM4, a calcium-activated non-selective cation channel implicated in cardiac conduction and immune response. In a notable 2013 study, Surbek successfully expressed, purified, and determined the projection structure of functional human TRPM4 using single-particle electron microscopy, a challenging feat given the protein's complexity and the heterologous expression system in Xenopus laevis oocytes. This work, though with 8 citations, provided foundational insights into TRPM4's architecture, paving the way for subsequent high-resolution studies. His achievements demonstrate a mastery of cutting-edge techniques in protein biochemistry and structural determination, advancing our understanding of ion channel mechanisms and their roles in human physiology and disease.
Research Focus
Key Achievements
Top Papers
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