Marc Baumann
Papers
1
Total Citations
8
H-Index
1
About
Marc Baumann is a structural biologist whose research centers on the molecular architecture of ion channels, particularly transient receptor potential (TRP) channels, using advanced electron microscopy techniques. His major contribution lies in pioneering methods for heterologous expression and single-particle electron microscopy of functional human membrane proteins, overcoming significant challenges in protein production and structural determination. His seminal 2013 work on human TRPM4, expressed in Xenopus laevis oocytes, achieved the first projection structure of this important calcium-activated channel, providing critical insights into its gating mechanisms. This foundational study has accrued 8 citations and established a technical framework for subsequent structural studies of TRP channels. Baumann’s work bridges the gap between functional electrophysiology and structural biology, enabling researchers to visualize dynamic channel conformations. His achievements include developing purification strategies that preserve channel functionality for EM analysis, a feat that has influenced the broader field of membrane protein structural biology. For students and researchers, Baumann exemplifies the power of combining classical expression systems with cutting-edge structural techniques to unravel the molecular basis of ion channel function.
Research Focus
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Top Papers
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