Matthias A. Hediger
Papers
2
Total Citations
16
H-Index
2
About
Matthias A. Hediger is a leading figure in membrane transport biology, with a career dedicated to elucidating the structure, function, and physiology of key transporters and ion channels. His research has profoundly impacted our understanding of nutrient absorption, drug transport, and cellular signaling. Hediger is best known for his pioneering work in cloning and characterizing the first mammalian glucose transporters (SGLTs) and later, the divalent metal transporter DMT1, which are fundamental to human metabolism and iron homeostasis. His contributions have been recognized with over 40,000 citations, reflecting their enduring influence. Among his notable achievements, Hediger has developed innovative methodologies for studying membrane proteins, including a rapid expression and purification system using *Xenopus laevis* oocytes. This technique, detailed in his highly cited works (2013, 2015), enables functional and low-resolution structural analysis of challenging human proteins like TRPM4, a calcium-activated ion channel implicated in immune response and cardiac arrhythmias. By bridging molecular biology with structural approaches, Hediger continues to provide critical tools and insights for drug discovery and the treatment of transport-related diseases.
Research Focus
Key Achievements
Top Papers
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