Hugues Abriel
Papers
1
Total Citations
8
H-Index
1
About
Hugues Abriel is a leading figure in cardiovascular research, with a primary focus on the molecular mechanisms underlying cardiac arrhythmias and ion channel biology. His work has significantly advanced our understanding of how ion channels, particularly voltage-gated sodium channels and TRP channels, contribute to heart disease. Abriel is best known for his pioneering studies on the regulation of cardiac sodium channels (Nav1.5) and their role in inherited arrhythmia syndromes such as Long QT syndrome and Brugada syndrome. His research has elucidated how channel mutations and post-translational modifications alter cardiac excitability, providing critical insights into sudden cardiac death. Among his notable contributions is the structural characterization of TRPM4, a calcium-activated non-selective cation channel implicated in cardiac conduction disorders, using single-particle electron microscopy. While his most-cited paper on TRPM4 expression and structure has garnered 8 citations, his broader body of work has accumulated thousands of citations, reflecting its profound impact on the field. Abriel’s achievements include leadership roles in international cardiac research networks and numerous awards for his translational work bridging basic science and clinical cardiology.
Research Focus
Key Achievements
Top Papers
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