Measurement of Peristaltic Forces Exerted by Living Intestine on Robotic Capsule

Abstract

Using robotic capsules for assessing gut health has been an emerging field since the early 2000s with researchers attempting to perform diagnosis, monitoring, and therapeutic functions inside the gut. The knowledge of peristaltic forces inside the intestine are crucial for designing the actuation mechanism of robotic capsules, however, the impact of peristalsis on a capsule has not yet been quantified. In this work, an analytical model is presented to study the peristaltic movement of the small intestine. For the first time, finite element simulations were conducted in COMSOL multiphysics to generate intestinal peristaltic forces, and analyze their impact on a robotic capsule. A capsule prototype (30 × φ12 mm) was developed to measure the peristaltic forces from living intestinal tissue, while an embedded system was used simultaneously to record the live data from the capsule-intestine interaction. In in vitro experiments, the intestine applied an average axial force of 226 mN and contraction cycles of 9 times/min, while the capsule prototype experienced maximum radial force of 180 mN. A specialized in vitro setup is developed to keep fresh ex vivo intestine samples alive for up to 6 h, while the capsule prototype measured the intestinal forces from the living tissue. This in vitro experimental setup provided an excellent model for the in vivo environment in terms of generating peristaltic movements, hence this force analysis will help in developing efficient prototypes for locomotion, anchoring, localization, biopsy, drug delivery, and sampling mechanisms for robotic capsules.