Liquid chromatography–mass spectrometry

Therapeutic drug monitoring and LC–MS/MS

Jo Adaway, Brian Keevil

Citations: 157 • 2011

An Automated Liquid Chromatography-Mass Spectrometry Process to Determine Metabolic Stability Half-Life and Intrinsic Clearance of Drug Candidates by Substrate Depletion

Colleen A. McNaney, Dieter M. Drexler, Serhiy Hnatyshyn, Tatyana Zvyaga, Jay O. Knipe, James V. Belcastro, Mark Sanders

Citations: 134 • 2008

Sequential Protein and Peptide Immunoaffinity Capture for Mass Spectrometry-Based Quantification of Total Human β-Nerve Growth Factor

Hendrik Neubert, David Muirhead, Musarat Kabir, Chris Grace, Adriaan Cleton, Rosalin Arends

Citations: 127 • 2012

Determination of a ‘GW cocktail’ of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry

Rebecca J. Scott, Jonathan Palmer, Ivor A. S. Lewis, Stephen Pleasance

Citations: 119 • 1999

Quantitative and Qualitative Determination of Estrogen Sulfates in Human Urine by Liquid Chromatography/Tandem Mass Spectrometry Using 96-Well Technology

Hongwei Zhang, Jack D. Henion

Citations: 118 • 1999

The Use of Automated Solid Phase Extraction in the '96 well' Format for High Throughput Bioanalysis using Liquid Chromatography Coupled to Tandem Mass Spectrometry

John P. Allanson, Robert Biddlecombe, Anne E. Jones, Stephen Pleasance

Citations: 116 • 1996

Simultaneous determination of four anthracyclines and three metabolites in human serum by liquid chromatography–electrospray mass spectrometry

F Lachâtre, Pierre Marquet, Sylvie Ragot, Jean‐Michel Gaulier, Philippe Cardot, J L Dupuy

Citations: 102 • 2000

Fully Automated 96-Well Liquid−Liquid Extraction for Analysis of Biological Samples by Liquid Chromatography with Tandem Mass Spectrometry

Sean Peng, Todd M. Branch, Salane King

Citations: 94 • 2000

A simple automated solid-phase extraction procedure for measurement of 25-hydroxyvitamin D ₃ and D ₂ by liquid chromatography-tandem mass spectrometry

Susan Knox, Lisa Calton, Andrew Wallace

Citations: 93 • 2009

Determination of the enantiomers of salbutamol and its 4-O-sulphate metabolites in biological matrices by chiral liquid chromatography tandem mass spectrometry

Karina B. Joyce, Anne E. Jones, Rebecca J. Scott, Robert Biddlecombe, Stephen Pleasance

Citations: 86 • 1998

Enantiomeric determination of tramadol and its main metabolite O-desmethyltramadol in human plasma by liquid chromatography–tandem mass spectrometry

Attilio Ceccato, Francis Vanderbist, J.-Y Pabst, Bruno Streel

Citations: 82 • 2000

Comparison of plasma sample purification by manual liquid–liquid extraction, automated 96-well liquid–liquid extraction and automated 96-well solid-phase extraction for analysis by high-performance liquid chromatography with tandem mass spectrometry

Mohammed Jemal, Deborah S. Teitz, Zheng Ouyang, Sanaullah Khan

Citations: 79 • 1999

Quantification of 31 illicit and medicinal drugs and metabolites in whole blood by fully automated solid-phase extraction and ultra-performance liquid chromatography–tandem mass spectrometry

Marie Kjærgaard Bjørk, Kirsten Wiese Simonsen, David W. Andersen, Petur Weihe Dalsgaard, Stella Rögn Sigurðardóttir, Kristían Línnet, Brian Schou Rasmussen

Citations: 77 • 2013

Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography–tandem mass spectrometry

Eliza N. Fung, Yung‐Hsiang Chen, Yau Yi Lau

Citations: 71 • 2003

An immunoaffinity liquid chromatography–tandem mass spectrometry assay for the quantitation of matrix metalloproteinase 9 in mouse serum

Mireia Fernández Ocaña, Hendrik Neubert

Citations: 69 • 2010

High-Throughput Mega-Method for the Analysis of Pesticides, Veterinary Drugs, and Environmental Contaminants by Ultra-High-Performance Liquid Chromatography−Tandem Mass Spectrometry and Robotic Mini-Solid-Phase Extraction Cleanup + Low-Pressure Gas Chromatography−Tandem Mass Spectrometry, Part 1: Beef

Sérgio Henrique Monteiro, Steven J. Lehotay, Yelena Sapozhnikova, Ederina Ninga, Alan R. Lightfield

Citations: 69 • 2020

Dried Blood Spot Proteomics: Surface Extraction of Endogenous Proteins Coupled with Automated Sample Preparation and Mass Spectrometry Analysis

Nicholas J. Martin, Josephine Bunch, Helen J. Cooper

Citations: 69 • 2013

Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin�) in human plasma

Lourdes Ramos, Ray Bakhtiar, Francis L. S. Tse

Citations: 66 • 2000

Introduction to early in vitro identification of metabolites of new chemical entities in drug discovery and development.

Paweł Baranczewski, Andrzej Stańczak, Antti Kautiainen, Per Sandin, Per‐Olof Edlund

Citations: 63 • 2006

Development and validation of a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the determination of ribavirin in human plasma and serum

Wilson Z. Shou, Hai‐Zhi Bu, Thomas Addison, Xiangyu Jiang, Naidong Weng

Citations: 62 • 2002