Colleen A. McNaney
Papers
2
Total Citations
171
H-Index
2
About
Colleen A. McNaney is a pharmaceutical scientist whose research has made significant contributions to the field of drug metabolism and pharmacokinetics, with a particular focus on developing automated, high-throughput analytical methodologies to support early-stage drug discovery. Her work centers on applying liquid chromatography-mass spectrometry (LC-MS) technologies to assess the metabolic stability of drug candidates, enabling faster and more efficient pharmaceutical profiling pipelines. Her most impactful contribution, a 2008 paper describing an automated process to determine metabolic stability half-life and intrinsic clearance via substrate depletion, has garnered 134 citations, reflecting its widespread adoption in the field. This work, alongside her 2007 development of the MetFast assay—an automated high-throughput approach to assess microsomal cytochrome P450-mediated metabolic stability—demonstrates her commitment to streamlining early drug candidate evaluation using robotic liquid handling and advanced mass spectrometry techniques. McNaney's research has had a meaningful impact on how pharmaceutical companies screen and prioritize drug candidates, reducing the time and resources required for critical absorption, distribution, metabolism, and excretion (ADME) assessments. Her methodological innovations continue to influence the design of modern pharmaceutical profiling workflows.
Research Focus
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