Xian Chen
Papers
1
Total Citations
95
H-Index
1
About
Xian Chen is a pioneering researcher in neurophotonics and bioengineering, whose work centers on developing wireless, implantable devices for non-invasive control of brain activity. His most cited study, "Tetherless near-infrared control of brain activity in behaving animals using fully implantable upconversion microdevices" (2017, 95 citations), represents a landmark contribution to the field. In this work, Chen introduced a fully implantable microdevice that converts near-infrared light into visible wavelengths, enabling precise, tether-free optogenetic modulation of neural circuits in freely behaving animals. This innovation overcomes the limitations of traditional fiber-optic tethers, offering a more naturalistic approach to studying brain function and behavior. By integrating upconversion nanoparticles with miniaturized electronics, Chen’s device achieves deep-tissue stimulation without external power sources, significantly advancing the toolkit for neuroscience research. His work has been widely cited for its potential to transform therapies for neurological disorders and to enable long-term, wireless neural interfacing. Chen’s contributions exemplify a blend of materials science, photonics, and neurobiology, positioning him as a leader in the next generation of brain-machine interfaces.
Research Focus
Key Achievements
Top Papers
- 1