Warren Thompson
Papers
4
Total Citations
18
H-Index
3
About
Warren Thompson is a medicinal and computational chemist whose research sits at the intersection of fragment-based drug discovery, high-throughput crystallography, and automated synthesis. His work addresses one of the most persistent bottlenecks in structure-based drug discovery: the efficient progression of weakly binding fragment hits into potent lead compounds. Thompson's landmark contribution, the Binding-Site Purification of Actives (B-SPA) methodology, ingeniously combines multi-step array synthesis with high-throughput crystallography to dramatically accelerate fragment hit elaboration at scale — a framework that has already attracted 9 citations since its 2025 publication. His earlier work demonstrated that low-cost robotics paired with crude array synthesis could yield rich crystallographic structural data, making sophisticated fragment progression workflows accessible to a broader research community. His Syndirella tool further advances the field by enabling synthesis-directed fragment elaboration, pushing compound diversity well beyond commercially available catalogues to more thoroughly explore binding sites and avoid premature chemical convergence. Collectively, Thompson's contributions are reshaping how researchers approach early-stage drug discovery, making the transformative promise of fragment-based approaches more practically achievable for both academic and industrial settings.
Research Focus
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Top Papers
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