Combinatorial chemistry

Peptoids: a modular approach to drug discovery.

Reyna J. Simon, Robert S. Kania, Ronald N. Zuckermann, Verena D. Huebner, David A. Jewell, Steven C. Banville, Simon Ng, L Wang, Stanley Rosenberg, Charles K. Marlowe

Citations: 939 • 1992

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

A. Buitrago Santanilla, Erik L. Regalado, Tony Pereira, Michael Shevlin, Kevin P. Bateman, Louis‐Charles Campeau, Jonathan E. Schneeweis, Simon Berritt, Zhicai Shi, Philippe G. Nantermet, Yong Liu, Roy Helmy, Christopher J. Welch, Petr Váchal, Ian W. Davies, Tim Cernak, Spencer D. Dreher

Citations: 647 • 2014

A Simple, High-Resolution Method for Establishing DNA Binding Affinity and Sequence Selectivity

Dale L. Boger, Brian E. Fink, S.R. Brunette, Winston C. Tse, Michael P. Hedrick

Citations: 536 • 2001

Semi‐Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery

Daniel G. Anderson, David M. Lynn, Róbert Langer

Citations: 507 • 2003

Combinatorial Heterogeneous Catalysis—A New Path in an Old Field

Selim Şenkan

Citations: 302 • 2001

Exploiting Nanospace for Asymmetric Catalysis: Confinement of Immobilized, Single-Site Chiral Catalysts Enhances Enantioselectivity

John Meurig Thomas, Robert Raja

Citations: 276 • 2008

Automated Library Generation Using Sequential Microwave-Assisted Chemistry. Application toward the Biginelli Multicomponent Condensation

Alexander Stadler, C. Oliver Kappe

Citations: 232 • 2001

Combinatorial compound libraries for drug discovery: an ongoing challenge

H. Mario Geysen, Frank J. Schoenen, David S. Wagner, Richard W. Wagner

Citations: 224 • 2003

Hybridisation based DNA screening on peptide nucleic acid (PNA) oligomer arrays

Jan Weiler

Citations: 219 • 1997

Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP

Shuvendu Biswas, Kazushi Kinbara, Tatsuya Niwa, Hideki Taguchi, Noriyuki Ishii, Sumiyo Watanabe, Kanjiro Miyata, Kazunori Kataoka, Takuzo Aida

Citations: 216 • 2013

High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis

Rebecca L. Greenaway, Valentina Santolini, Michael J. Bennison, Ben M. Alston, C. J. Pugh, Marc A. Little, Marcin Miklitz, E. G. B. Eden-Rump, Rob Clowes, A. Shakil, H. J. Cuthbertson, H. Armstrong, Michael E. Briggs, Kim E. Jelfs, Andrew I. Cooper

Citations: 215 • 2018

Closed-loop optimization of general reaction conditions for heteroaryl Suzuki-Miyaura coupling

Nicholas H. Angello, Vandana Rathore, Wiktor Beker, Agnieszka Wołos, Edward R. Jira, Rafał Roszak, Tony Wu, Charles M. Schroeder, Alán Aspuru‐Guzik, Bartosz A. Grzybowski, Martin D. Burke

Citations: 209 • 2022

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery

Daniel J. Siegwart, Kathryn A. Whitehead, Lutz Nuhn, Gaurav Sahay, Hao Cheng, Shan Jiang, Minglin Ma, Abigail K. R. Lytton‐Jean, Arturo J. Vegas, Patrick Fenton, Christopher G. Levins, Kevin T. Love, Haeshin Lee, Christina Cortez, Sean P. Collins, Ying Fei Li, Janice Jang, William Querbes, Christopher Zurenko, Tatiana I. Novobrantseva, Róbert Langer, Daniel G. Anderson

Citations: 200 • 2011

Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides

Holger Wenschuh, Rudolf Volkmer, Margit Schmidt, Marco Schulz, Jens Schneider‐Mergener, Ulrich Reineke

Citations: 199 • 2000

Stereodivergent synthesis with a programmable molecular machine

Salma Kassem, Alan T. L. Lee, David A. Leigh, Vanesa Marcos, Leoni I. Palmer, Simone Pisano

Citations: 177 • 2017

Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries

Citations: 177 • 1998

Covalent Adaptable Liquid Crystal Networks Enabled by Reversible Ring-Opening Cascades of Cyclic Disulfides

Shuai Huang, Yikang Shen, Hari Krishna Bisoyi, Tao Yu, Zhongcheng Liu, Meng Wang, Hong Yang, Quan Li

Citations: 171 • 2021

Iterative High-Throughput Polymorphism Studies on Acetaminophen and an Experimentally Derived Structure for Form III

Matthew L. Peterson, Sherry L. Morissette, Chris McNulty, Andrew M. Goldsweig, Paul Shaw, Martin LeQuesne, Julie Monagle, Nicolas Encina, Joseph Marchionna, Alasdair Johnson, Javier P. Gonzalez-Zugasti, Anthony V. Lemmo, Stephen J. Ellis, Michael J. Cima, Örn Almarsson

Citations: 152 • 2002

The Combinatorial Approach to Asymmetric Hydrogenation: Phosphoramidite Libraries, Ruthenacycles, and Artificial Enzymes

Johannes G. de Vries, Laurent Lefort

Citations: 135 • 2006

Effects of NHC-Backbone Substitution on Efficiency in Ruthenium-Based Olefin Metathesis

Kevin M. Kuhn, J.-B. Bourg, Cheol K. Chung, Scott C. Virgil, Robert H. Grubbs

Citations: 129 • 2009