Tracy Guillemette
Papers
1
Total Citations
31
H-Index
1
About
Tracy Guillemette is a molecular biologist whose research focuses on the intersection of viral oncogenesis and cellular immortalization, particularly in the context of cervical cancer. Her most-cited work, a 2002 study on insulin-like growth factor-binding protein 3 (IGFBP-3) expression, demonstrated that IGFBP-3 levels increase during the immortalization of cervical keratinocytes by human papillomavirus type 16 (HPV-16) E6 and E7 proteins. This finding provided critical insight into how HPV disrupts normal growth regulation, linking viral proteins to the IGF signaling axis—a key pathway in cancer progression. With 31 citations, this paper has informed subsequent studies on HPV-driven malignancies and the role of IGFBP-3 as a potential biomarker. Guillemette’s contributions have helped clarify the molecular mechanisms by which HPV establishes persistent infection and drives cellular transformation, offering a foundation for targeted therapeutic strategies. Her work remains relevant to researchers exploring viral-host interactions and the early stages of carcinogenesis.
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