Stephen D. Dertinger
Papers
4
Total Citations
203
H-Index
4
About
Stephen D. Dertinger is a prominent researcher in genetic toxicology and genotoxicity assessment, whose work has significantly advanced the field of high-throughput DNA damage detection. His research centers on developing innovative flow cytometric assays that can simultaneously measure multiple biomarkers of genotoxic stress, enabling more efficient and informative safety evaluations of chemical compounds. Dertinger's most influential contribution is the development and validation of the MultiFlow™ DNA Damage Kit, a multiplexed assay that detects key genotoxicity biomarkers — including γH2AX, p53, and phospho-histone H3 — while distinguishing between clastogens, aneugens, and nongenotoxicants. His landmark 2016 paper, which garnered 87 citations, demonstrated how machine learning could be integrated with this platform to predict genotoxic modes of action, representing a meaningful leap forward in predictive toxicology. A subsequent interlaboratory validation study (74 citations) confirmed the assay's reproducibility across multiple testing sites, a critical milestone for regulatory acceptance. His more recent work explores metabolic activation strategies compatible with 3Rs principles, broadening the assay's applicability. Across his career, Dertinger has championed smarter, more humane, and scientifically rigorous approaches to genetic safety testing, making him a key figure in modernizing genotoxicology methodology.
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