Sabrina Wilde
Papers
1
Total Citations
74
H-Index
1
About
Dr. Sabrina Wilde is a leading toxicologist whose work has significantly advanced the field of genetic toxicology and in vitro safety assessment. Her research centers on developing and validating high-throughput, mechanism-based assays to detect DNA damage and predict carcinogenic risk, moving beyond traditional methods. Her most notable contribution is the development of a multiplexed in vitro genotoxicity assay that uses flow cytometry to simultaneously measure multiple key biomarkers of DNA damage—including p53 activation, γH2AX foci formation, and phospho-histone H3—in a single, rapid test. This innovative approach, detailed in her highly cited 2017 paper (74 citations), provides a more comprehensive and biologically relevant picture of genotoxic potential. Dr. Wilde has been instrumental in leading interlaboratory evaluations to validate this assay for regulatory use, demonstrating its robustness and reproducibility. Her work is pivotal in refining how chemical safety is assessed, reducing reliance on animal testing while improving the accuracy of hazard identification for pharmaceuticals and industrial chemicals.
Research Focus
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