Karen Zeise
Papers
1
Total Citations
12
H-Index
1
About
Karen Zeise is a leading toxicologist whose research focuses on advancing genetic toxicology through innovative, high-throughput methodologies that align with the 3Rs (Replacement, Reduction, and Refinement) principles. Her major contribution is the development of the MultiFlow® DNA Damage assay—a miniaturized, flow cytometry-based platform that simultaneously measures p53, γH2AX, and Phospho-Histone H3 in the p53-competent human TK6 cell line. This breakthrough enables rapid, mechanistic discrimination between clastogens, aneugens, and nongenotoxicants, offering a more ethical and efficient alternative to traditional animal-based testing. Her most cited work (2020, 12 citations) exemplifies this approach, demonstrating how exogenous metabolic activation can be integrated into high-throughput screens without sacrificing accuracy. Zeise’s impact is evident in the growing adoption of her methods by regulatory and pharmaceutical laboratories, streamlining early-stage hazard identification. Her commitment to refining toxicological assays not only reduces animal use but also enhances data quality, positioning her as a key figure in the shift toward modern, mechanism-driven safety assessment.
Research Focus
Key Achievements
Top Papers
- 1