Snezana Drmanac

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About

Snezana Drmanac is a pioneering molecular biologist whose work has fundamentally shaped the field of DNA sequencing. Her key research areas include sequencing by hybridization (SBH), high-throughput genomic analysis, and the development of cost-effective, large-scale DNA sequencing technologies. Drmanac’s major contribution is the conceptualization and early implementation of an automated SBH method capable of determining up to 100 million base pairs per year—a revolutionary leap at the time. Her 1992 paper, “Sequencing by hybridization: Towards an automated sequencing of one million M13 clones arrayed on membranes,” has accumulated 46 citations and laid the groundwork for modern array-based sequencing approaches. This work introduced a six-step process involving the arraying of genomic or cDNA clones, which directly influenced the development of later high-throughput platforms. Drmanac’s innovations were critical in demonstrating that hybridization-based methods could be scaled for whole-genome analysis, making sequencing more accessible and efficient. Her achievements have been instrumental in advancing the Human Genome Project and subsequent genomic research, cementing her legacy as a key architect of the sequencing revolution.