Aleksandra Vicentic
Papers
1
Total Citations
46
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1
About
Aleksandra Vicentic is a pioneering figure in the development of high-throughput genomic technologies, with her most influential work centering on sequencing by hybridization (SBH). Her landmark 1992 paper, which has garnered 46 citations, introduced a practical and scalable variant of SBH, proposing a method capable of determining up to 100 million base pairs per year. This work laid the conceptual and technical groundwork for automated, array-based DNA sequencing, directly addressing the challenge of processing large numbers of M13 clones. By detailing a six-step process from arraying clones to hybridization analysis, Vicentic’s contribution was immediately applicable, helping to bridge the gap between theoretical sequencing approaches and real-world, high-volume laboratory implementation. Her research is a key early milestone in the evolution of genomic technologies, demonstrating the feasibility of massively parallel sequencing strategies that would later underpin the Human Genome Project. For students and researchers, Vicentic’s work exemplifies how methodical engineering of biological assays can dramatically accelerate the pace of discovery, making her a notable figure in the history of genomics.
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