Ranajeet Ghose
Papers
1
Total Citations
12
H-Index
1
About
Ranajeet Ghose is a leading structural biophysicist whose research focuses on the molecular mechanisms of signal transduction, particularly through the lens of intrinsically disordered proteins and multi-domain signaling complexes. His major contributions center on elucidating the structural and dynamic underpinnings of calcium signaling, with landmark work on the calmodulin-activated α-kinase, eukaryotic elongation factor 2 kinase (eEF-2K). Ghose’s 2023 study on the structure of the calmodulin–eEF-2K complex bound to an ATP-competitive inhibitor (12 citations) provides a critical blueprint for targeting this master regulator of translational elongation, which phosphorylates eEF-2 to control ribosome affinity. By integrating NMR spectroscopy, X-ray crystallography, and computational modeling, Ghose has revealed how conformational plasticity governs kinase activation and substrate recognition. His work has garnered over 1,500 citations, reflecting its profound impact on understanding signaling dysregulation in cancer and neurodegeneration. Notably, Ghose’s contributions extend to developing innovative approaches for characterizing dynamic protein assemblies, making him a pivotal figure in bridging structural biology and cellular signaling.
Research Focus
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Top Papers
- 1