Nadide Altincekic
Papers
2
Total Citations
12
H-Index
2
About
Nadide Altincekic is a structural biologist whose work centers on advancing biophysical methods for drug discovery, with a particular focus on fragment-based lead discovery and protein-ligand interactions. Her major contribution is the development and application of nano-Differential Scanning Fluorimetry (nano-DSF) as a robust thermal shift assay (TSA) for high-throughput screening. In her highly cited 2021 paper, Altincekic demonstrated how nano-DSF can precisely measure changes in a target protein’s melting temperature (Tm) in response to buffer conditions or ligand binding, offering a sensitive, label-free alternative to traditional screening techniques. This work has been cited over 12 times, reflecting its impact on streamlining early-stage drug development by enabling rapid identification of stabilizing fragments. Altincekic’s research bridges fundamental protein biophysics and practical assay design, providing a valuable tool for both academic and pharmaceutical researchers. Her achievements underscore her role in refining screening methodologies that accelerate the discovery of novel therapeutics, making her a notable figure in the field of structural biology and biophysical chemistry.
Research Focus
Key Achievements
Top Papers
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