Papers
11
Total Citations
427
H-Index
8
About
Matthias Mann stands as a transformative figure in the field of mass spectrometry-based proteomics, whose decades of innovation have fundamentally shaped how scientists identify, quantify, and characterize proteins at scale. His early pioneering work in laboratory automation — including the development of robotic systems for parallel protein sample preparation and enzymatic cleavage of gel-separated proteins in the mid-1990s — laid essential groundwork for high-throughput proteomics workflows that the field still builds upon today. Mann's contributions span intelligent data acquisition frameworks for shotgun proteomics, orthogonal MALDI tandem mass spectrometry for peptide sequencing, and immunoproteomics strategies combining antibody-based enrichment with stable isotope labeling for absolute protein quantification. His more recent work pushes boundaries further still, with spatial proteomics enabling protein mapping within three-dimensional intact tissue specimens (114 citations) and IMBAS-MS uncovering organ-specific HLA peptide signatures directly from plasma. From early explorations of the Drosophila proteome to cutting-edge clinical immunopeptidomics powered by deep learning tools like AlphaPeptDeep, Mann's career represents an extraordinary arc of methodological creativity, consistently delivering tools that empower the broader biomedical research community to ask — and answer — previously intractable biological questions.
Research Focus
Key Achievements
Top Papers
- 1Spatial proteomics in three-dimensional intact specimens114 citations · 2022
- 2
- 3
- 4Automated Protein Preparation Techniques Using a Digest Robot42 citations · 1997
- 5Peptide End Sequencing by Orthogonal MALDI Tandem Mass Spectrometry35 citations · 2002
- 6
- 7
- 8IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma24 citations · 2023
- 9A boundless future for proteomics?8 citations · 2001
- 10