Lai F. Bergeman
Great Lakes Bioenergy Research Center, University of Wisconsin–Madison
Papers
2
Total Citations
23
H-Index
2
About
Lai F. Bergeman’s research centers on advancing high-throughput biotechnologies for protein production and enzyme discovery, with a particular focus on glycoside hydrolases (GHs) and structural biology. Their most cited work, “Development of a High Throughput Platform for Screening Glycoside Hydrolases Based on Oxime-NIMS” (2015, 15 citations), introduced a cost-effective, oxime-based nanostructure-initiator mass spectrometry (NIMS) platform for rapidly screening GH activity. This innovation directly addresses the challenge of improving enzyme cocktails for biomass hydrolysis into fermentable sugars—a critical step toward sustainable biofuel production. By enabling faster identification of high-performance GHs under demanding industrial conditions, Bergeman’s platform accelerates the development of more efficient and economical biofuel processes. In earlier work, “Rapid, robotic, small‐scale protein production for NMR screening and structure determination” (2010, 8 citations), Bergeman tackled a bottleneck in structural genomics: the low success rate of protein targets for NMR. By implementing a streamlined, robotic pipeline for small-scale expression and purification, they dramatically increased throughput for validating proteins suitable for three-dimensional structure determination. Together, these contributions highlight Bergeman’s impact in merging automation with analytical chemistry to solve practical challenges in renewable energy and structural biology, offering scalable tools that reduce cost and time in enzyme and protein research.
Research Focus
Key Achievements
Top Papers
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