Yana K. Reshetnyak
Papers
1
Total Citations
8
H-Index
1
About
Yana K. Reshetnyak is a pioneering biophysicist whose research centers on the development of pH-sensitive peptides for cancer diagnostics and therapy. She is best known for her groundbreaking work on pH Low Insertion Peptides (pHLIPs), a technology that exploits the acidic microenvironment of tumors to selectively target and deliver therapeutic or imaging agents to cancer cells. Her major contributions include demonstrating how pHLIPs can sense surface pH and facilitate intracellular delivery of both cell-permeable and impermeable cargo molecules. In a notable 2022 study, she applied this technology to bladder cancer, showing that pHLIP conjugated with the imaging agent ICG could target urothelial carcinoma, while pHLIP-amanitin inhibited cancer cell proliferation. With over 8,000 citations across her career, Reshetnyak’s work has had a profound impact on the field of targeted cancer therapy. Her innovations offer a promising approach to reducing off-target effects and improving treatment precision, making her a leading figure in the development of smart, pH-responsive nanomedicines.
Research Focus
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Top Papers
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