Papers
2
Total Citations
27
H-Index
2
About
T. Barthel is a structural biologist whose work centers on advancing crystallographic fragment screening—a powerful technique for identifying small-molecule starting points in drug discovery. Based at the Helmholtz-Zentrum Berlin (HZB), Barthel has made pivotal contributions to the development and optimization of workflows and tools that enable high-throughput, high-resolution X-ray diffraction experiments for fragment-based ligand design. Their most-cited publication, "Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin" (2021), has accumulated 27 citations, reflecting its importance as a practical guide for researchers in the field. This work details the integration of automated data collection, sample handling, and analysis pipelines, making crystallographic screening more accessible and reproducible. By streamlining the process from crystal preparation to hit identification, Barthel has helped establish HZB as a key facility for fragment screening, supporting both academic and pharmaceutical research. Their efforts are particularly valuable for scientists seeking efficient methods to explore chemical space and accelerate early-stage drug development. Barthel’s contributions exemplify how methodological innovation in structural biology can directly impact translational research.
Research Focus
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Top Papers
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