Martin Gerlach
Papers
2
Total Citations
27
H-Index
2
About
Martin Gerlach is a structural biologist whose work centers on advancing crystallographic fragment screening as a powerful tool for early-stage drug discovery. His major contributions lie in developing and optimizing the experimental workflows and computational tools that make high-throughput fragment screening at synchrotron facilities both efficient and reproducible. Gerlach’s research addresses a critical bottleneck in ligand design: the need for robust, high-resolution X-ray diffraction data from protein crystals. By refining protocols at the Helmholtz-Zentrum Berlin, he has helped establish crystallography as a preferred method for identifying promising chemical starting points for new therapeutics. His most-cited work, a 2021 paper detailing these workflows and tools, has accumulated 27 citations, reflecting its practical value to the structural biology and drug design communities. Through this foundational methodology, Gerlach enables researchers to systematically screen small molecular fragments, accelerating the path from protein structure to viable lead compounds. His achievements underscore the importance of method development in transforming raw crystallographic data into actionable insights for medicinal chemistry.
Research Focus
Key Achievements
Top Papers
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