Michael Hellmig
Papers
2
Total Citations
27
H-Index
2
About
Michael Hellmig is a structural biologist at the Helmholtz-Zentrum Berlin whose work centers on advancing crystallographic fragment screening—a powerful technique for identifying small-molecule starting points in drug discovery. His major contribution lies in the development and optimization of the end-to-end workflow and tools that enable high-throughput, high-resolution X-ray diffraction-based fragment screening at synchrotron facilities. By streamlining the process from crystal handling to data analysis, Hellmig has made this method more accessible and reproducible for the broader structural biology community. His landmark 2021 publication, which has accumulated over 27 citations, serves as a practical guide for researchers seeking to implement crystallographic screening, detailing the automated sample mounting, data collection strategies, and computational pipelines that underpin successful campaigns. This work has directly impacted the efficiency of early-stage ligand design, helping to bridge the gap between protein structure determination and therapeutic development. Hellmig’s contributions are particularly valuable for students and researchers entering the field of fragment-based drug discovery, offering a clear, methodical framework for tackling one of the most challenging steps in rational drug design.
Research Focus
Key Achievements
Top Papers
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