Papers
2
Total Citations
55
H-Index
2
About
Hidenori Arai is a leading geriatrician whose research bridges molecular mechanisms of aging with pressing public health challenges. His seminal work on diabetic nephropathy demonstrated that advanced glycation end products (AGEs) drive kidney damage by upregulating the collagen chaperone HSP47, and that the inhibitor OPB-9195 can block this pathway—a finding with over 50 citations that has shaped understanding of diabetic complications. More recently, Arai has turned his expertise to health system resilience, authoring a pivotal opinion for the Science Council of Japan on reconstructing medical care in the COVID-19 era. This piece, which addresses the disproportionate risk to older adults and regional health disparities, reflects his commitment to translating bench research into real-world policy. As a prominent voice in Japanese gerontology, Arai’s career exemplifies how deep mechanistic insight—from AGEs to HSP47—can inform both clinical targets and the infrastructure needed to protect vulnerable populations during crises.
Research Focus
Key Achievements
Top Papers
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