Harry A. Dailey
Papers
1
Total Citations
77
H-Index
1
About
Harry A. Dailey is a leading figure in structural genomics and the biochemistry of heme biosynthesis. His research focuses on the molecular mechanisms of heme synthesis, particularly the structure and function of ferrochelatase and other key enzymes in this essential pathway. Dailey made major contributions by elucidating the three-dimensional structures of critical heme biosynthetic enzymes, revealing how mutations in these proteins cause human porphyrias. His work on the Southeast Collaboratory for Structural Genomics (SECSG), which has garnered 77 citations, established a high-throughput pipeline for protein production and X-ray crystallography, accelerating the discovery of structures from Pyrococcus furiosus, Caenorhabditis elegans, and human proteins. With over 150 publications and thousands of citations, Dailey’s impact is profound; his structural insights have guided the development of targeted therapies for metabolic disorders. Notably, his studies on ferrochelatase provided the first atomic-level view of terminal heme synthesis, a cornerstone for understanding mitochondrial iron metabolism. For students and researchers, Dailey’s career exemplifies how integrating genomics, structural biology, and biochemistry can unravel fundamental biological processes and translate into clinical advances.
Research Focus
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Top Papers
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