James H. Prestegard

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About

James H. Prestegard is a pioneering figure in structural biology, whose work has fundamentally advanced our understanding of biomolecular structure and dynamics. His research centers on the development and application of nuclear magnetic resonance (NMR) spectroscopy, with a particular focus on membrane proteins, glycolipids, and carbohydrate–protein interactions. Prestegard is renowned for introducing residual dipolar couplings (RDCs) as a tool for structure determination in solution NMR, a breakthrough that has enabled the study of larger, more complex molecular systems. He also played a key leadership role in the Southeast Collaboratory for Structural Genomics, a high-throughput gene-to-structure pipeline that produced structures for proteins from *Pyrococcus furiosus*, *Caenorhabditis elegans*, and humans, earning over 77 citations. His work has been cited more than 15,000 times, reflecting its profound impact on both methodology and biological insight. A member of the National Academy of Sciences, Prestegard has shaped the field through decades of innovative research at the University of Georgia, where he continues to inspire students and researchers to push the boundaries of structural biology.