Gemma C. Ordidge
Papers
1
Total Citations
13
H-Index
1
About
Dr. Gemma C. Ordidge is a bioprocess scientist whose work focuses on the critical challenge of protein refolding, a key bottleneck in the production of therapeutic proteins. Her major contribution lies in the development of a generic, high-throughput screening method for optimizing the refolding of proteins derived from inclusion bodies. This approach, detailed in her most-cited paper (13 citations), leverages an automated robotic platform to systematically test hundreds of refolding conditions, dramatically accelerating what was previously a slow, empirical process. By introducing a hierarchical screening strategy, Dr. Ordidge’s work enables researchers to rapidly identify optimal buffer compositions and dilution factors, improving both yield and activity of target proteins. This innovation directly addresses a long-standing inefficiency in bioprocess development, offering a scalable solution for the pharmaceutical industry. Her research is particularly valuable for students and scientists working on recombinant protein production, providing a practical framework to overcome the low-yield challenges that often plague the refolding step.
Research Focus
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Top Papers
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