Martina Micheletti
Papers
4
Total Citations
50
H-Index
4
About
Martina Micheletti is a leading figure in microscale bioprocessing, whose work has fundamentally advanced the high-throughput optimization of biopharmaceutical production. Her research centers on developing automated, miniaturized platforms to streamline the notoriously complex steps of cell disruption, protein refolding, and bioconversion. Micheletti’s major contributions include pioneering microscale techniques to evaluate cell disruption for releasing antibody fragments from *E. coli*, and creating an integrated robotic platform for oxidative bioconversion processes using cyclohexanone monooxygenase. She also developed a hierarchical screening method for optimizing protein refolding from inclusion bodies—a critical bottleneck in manufacturing—and a novel microscale crossflow device for rapid microfiltration evaluation. Her most cited works, including studies on cell disruption effects (14 citations) and automated bioconversion (13 citations), have collectively demonstrated the power of microscale tools to accelerate process development while reducing material consumption. By translating industrial-scale challenges into efficient, automated microtiter plate formats, Micheletti has established a framework that enables researchers to screen dozens of conditions simultaneously, significantly shortening the timeline from discovery to production. Her innovative approach continues to shape the future of bioprocess engineering, making her work essential reading for students and researchers seeking to modernize biomanufacturing.
Research Focus
Key Achievements
Top Papers
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