Bioavailability

Metabolic Stability for Drug Discovery and Development

Collen Masimirembwa, Ulf Bredberg, Tommy B. Andersson

引用数: 219 • 2003

RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract

Shriya S. Srinivasan, Amro Alshareef, Alexandria Hwang, Ziliang Kang, Johannes Kuosmanen, Keiko Ishida, J. A. Jenkins, Sabrina Liu, Wiam Abdalla Mohammed Madani, Jochen K. Lennerz, Alison Hayward, Joshua Morimoto, Nina Fitzgerald, Róbert Langer, Giovanni Traverso

引用数: 114 • 2022

A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects

Arvinder K. Dhalla, ZIAD T. AL-SHAMSIE, Simret Beraki, Anvesh Dasari, Leonard C. Fung, Laura Fusaro, Anusha Garapaty, Betsy Gutierrez, Delia Gratta, Mir A. Hashim, Kyle Horlen, Padma Karamchedu, Radhika Korupolu, Eric Liang, Chang Ong, Zachary Owyang, Vasudha Salgotra, Shilpy Sharma, Baber Syed, Mansoor Ali Syed, April Toledo Vo, Radia Abdul‐Wahab, Asad Wasi, Alyson Yamaguchi, Shane Yen, Mir Imran

引用数: 94 • 2021

Robotically handled whole-tissue culture system for the screening of oral drug formulations

Thomas von Erlach, Sarah H. Saxton, Yunhua Shi, Daniel Minahan, Daniel Reker, Farhad Javid, Young‐Ah Lucy Lee, Carl M. Schoellhammer, Tina Esfandiary, Cody Cleveland, Lucas Booth, Jiaqi Lin, Hannah Levy, Sophie M. Blackburn, Alison Hayward, Róbert Langer, Giovanni Traverso

引用数: 52 • 2020

Enhanced Bioavailability of a Poorly Water-Soluble Weakly Basic Compound Using a Combination Approach of Solubilization Agents and Precipitation Inhibitors: A Case Study

Shu Li, Crystal Pollock‐Dove, Dong Liang, Jing Chen, Abla A. Creasey, Weiguo Dai

引用数: 41 • 2012

Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments

Cecilie Maria Madsen, Kung‐I Feng, Andrew Leithead, Nicole Canfield, Søren Astrup Jørgensen, Anette Müllertz, Thomas Rades

引用数: 36 • 2017

Parallel screening approach to identify solubility-enhancing formulations for improved bioavailability of a poorly water-soluble compound using milligram quantities of material

Weiguo Dai, Dong Liang, Shu Li, Crystal Pollock‐Dove, Jing Chen, P. Mansky, Gary Eichenbaum

引用数: 35 • 2006

Coumarins permeability in Caco-2 cell model

Anna Galkin, Adyary Fallarero, Pia Vuorela

引用数: 26 • 2009

A Microalgae‐Probiotic‐Nanozyme Robot for Alleviating Intestinal Inflammation and Microbiota Dysbiosis

Jinjie Hou, Anlai Zou, Xiaoxue Zhu, Ruijie Fu, Yunlei Xianyu

引用数: 22 • 2025

Coumarins permeability in Caco-2 cell model

Anna Galkin, Adyary Fallarero, Pia Vuorela

引用数: 17 • 2009

Electromechanical convective drug delivery devices for overcoming diffusion barriers

Ji Hoon Park, Ramy Ghanim, Adwik Rahematpura, Caroline Gerage, Alex Abramson

引用数: 11 • 2024

Nanorobot Drug Delivery System for Curcumin for Enhanced Bioavailability during Treatment of Alzheimer’s Disease

Kal Renganathan Sharma

引用数: 11 • 2013

Chiral assay methods for lifibrol and metabolites in plasma and the observation of unidirectional chiral inversion following administration of the enantiomers to dogs

Rodney R. Walters, Chang‐Yuan L. Hsu

引用数: 11 • 1994

Micro/nanorobots for gastrointestinal tract

Ziqi Sui, Chugen Wan, Bin Yang

引用数: 7 • 2024

Food interaction pharmacokinetic study of cordaflex 20 mg retard filmtablet in healthy volunteers.

Katalin Nemes, Viola Horváth, G. Grézal, G. Horvai, Andrea Hrabéczy-Páll, E. Kocsi, Sándor Drabant, M. Csörgó, G. Renczes, Imre Klebovich

引用数: 5 • 1998

Transenteric delivery of antibodies via an orally ingestible robotic pill yields high bioavailability comparable to parenteral administration in awake canines

Alyson Yamaguchi, Jacques Van Dam, Arvinder K. Dhalla, Kyle Horlen, Mir Imran, April Toledo Vo, Mir A. Hashim

引用数: 4 • 2022

Quantification of Ibuprofen in human plasma by using High Throughput Liquid Chromatographyâtandem mass spectrometric method and its applications in pharmacokinetics

Raghunadha Reddy Seelam Nageswara Rao Pilli Ravindra Reedy S, I.Sarath ch, K. N. Jayaveera, Koteswara Rao.Divi

引用数: 4 • 2010

An oral robotic pill reliably and safely delivers teriparatide with high bioavailability in healthy volunteers: A phase 1 study

Joshua Myers, Alyson Yamaguchi, April Toledo Vo, Anvesh Dasari, Archana Battiwala, Nidhi Patel, Leonard C. Fung, Ofer M. Gonen, Mir Imran, Jacques Van Dam, Mir A. Hashim, Arvinder K. Dhalla, J P Bilezikian

引用数: 3 • 2025

SAT235 An Orally Administered Robotic Pill (RP) Reliably And Safely Delivers the Human Parathyroid Hormone Analog hPTH(1-34) (Teriparatide) With High Bioavailability in Healthy Human Volunteers: A Phase 1 Study

Joshua T Myers, Anvesh Dasari, Archana Battiwala, Nidhi Patel, April Toledo Vo, Alyson Yamaguchi, Kyle Horlen, Leonard C. Fung, Baber Syed, Son Truong Nguyen, Jacques Van Dam, Mir Imran, Mir A. Hashim, Arvinder K. Dhalla

引用数: 2 • 2023

AN ORALLY ADMINISTERED ROBOTIC PILL (RP) RELIABLY AND SAFELY DELIVERS AN USTEKINUMAB BIOSIMILAR WITH HIGH BIOAVAILABILITY RELATIVE TO SUBCUTANEOUS (SC) USTEKINUMAB IN HEALTHY HUMAN PARTICIPANTS

Joshua Myers, Son Truong Nguyen, Nidhi Patel, April Toledo Vo, Alyson Yamaguchi, Kyle Horlen, Baber Syed, Jacques Van Dam, Mir Imran, Mir A. Hashim, Arvinder K. Dhalla

引用数: 2 • 2024