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Membrane Biochips

Fang Ye, Anthony G. Frutos, Brian Webb, Yulong Hong, Ann M. Ferrie, Fang Lai, Joydeep Lahiri

发表年份
2002
引用次数
13
访问权限
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摘要

Membrane-bound proteins represent the single most important class of drug targets. This article discusses the issues surrounding fabrication of membrane–protein microarrays by conventional robotic pin printing techniques. Ligand binding selectivity and specificity to G protein-coupled receptor (GPCR) microarrays are presented. The potential applications of these arrays for drug screening are discussed.

关键词

BiochipDNA microarrayG protein-coupled receptorComputational biologyProtein microarrayMembrane proteinMembraneMicroarrayLigand (biochemistry)Biology

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