Protein precipitation

High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS/MS

Øivind Midttun, Gry Kvalheim, Per Magne Ueland

Citations: 133 • 2012

Higher Throughput Bioanalysis by Automation of a Protein Precipitation Assay Using a 96-Well Format with Detection by LC−MS/MS

Alan P. Watt, Denise Morrison, Karen L Locker, David C. Evans

Citations: 119 • 2000

Simultaneous determination of four anthracyclines and three metabolites in human serum by liquid chromatography–electrospray mass spectrometry

F Lachâtre, Pierre Marquet, Sylvie Ragot, Jean‐Michel Gaulier, Philippe Cardot, J L Dupuy

Citations: 102 • 2000

A simple automated solid-phase extraction procedure for measurement of 25-hydroxyvitamin D ₃ and D ₂ by liquid chromatography-tandem mass spectrometry

Susan Knox, Lisa Calton, Andrew Wallace

Citations: 93 • 2009

Simultaneous determination of plasma epinephrine and norepinephrine using an integrated strategy of a fully automated protein precipitation technique, reductive ethylation labeling and UPLC–MS/MS

Chengjie Ji, Justin Walton, Yi Su, Max Tella

Citations: 91 • 2010

Determination of the enantiomers of salbutamol and its 4-O-sulphate metabolites in biological matrices by chiral liquid chromatography tandem mass spectrometry

Karina B. Joyce, Anne E. Jones, Rebecca J. Scott, Robert Biddlecombe, Stephen Pleasance

Citations: 86 • 1998

Automated protein precipitation by filtration in the 96-well format

Robert Biddlecombe, Stephen Pleasance

Citations: 82 • 1999

A fully automated plasma protein precipitation sample preparation method for LC–MS/MS bioanalysis

Ji Ma, Jianxia Shi, Hoa Thi Le, Robert Cho, Judy Chi-jou Huang, Shichang Miao, Bradley K. Wong

Citations: 73 • 2007

Development and validation of a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the determination of ribavirin in human plasma and serum

Wilson Z. Shou, Hai‐Zhi Bu, Thomas Addison, Xiangyu Jiang, Naidong Weng

Citations: 62 • 2002

Automated microanalysis of gabapentin in human serum by high-performance liquid chromatography with fluorometric detection

Peter Tang, Michael V. Miles, Tracy A. Glauser, Ton J. deGrauw

Citations: 57 • 1999

High-throughput protein precipitation and hydrophobic interaction chromatography: Salt effects and thermodynamic interrelation

Beckley K. Nfor, Nienke N. Hylkema, Koenraad R. Wiedhaup, Peter Verhaert, Luuk A. M. van der Wielen, Marcel Ottens

Citations: 51 • 2011

Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography–tandem mass spectrometry

Rachel R. Taylor, Keith L. Hoffman, Björn Schniedewind, Claudia Clavijo, Jeffrey L. Galinkin, Uwe Christians

Citations: 50 • 2013

Quantification of Apixaban, Dabigatran, Edoxaban, and Rivaroxaban in Human Serum by UHPLC-MS/MS—Method Development, Validation, and Application

Sofia Lindahl, Roar Dyrkorn, Olav Spigset, Solfrid Hegstad

Citations: 50 • 2018

An improved and fully validated LC–MS/MS method for the simultaneous quantification of simvastatin and simvastatin acid in human plasma

Constantinos Apostolou, Constantinos Kousoulos, Yannis Dotsikas, Georgios-Stefanos Soumelas, Filomila Kolocouri, Afroditi Ziaka, Yannis L. Loukas

Citations: 42 • 2007

Enhanced Bioavailability of a Poorly Water-Soluble Weakly Basic Compound Using a Combination Approach of Solubilization Agents and Precipitation Inhibitors: A Case Study

Shu Li, Crystal Pollock‐Dove, Dong Liang, Jing Chen, Abla A. Creasey, Weiguo Dai

Citations: 41 • 2012

Performance of an ultra‐low elution‐volume 96‐well plate: drug discovery and development applications

Claude R. Mallet, Ziling Lu, Ray P. Fisk, Jeffrey R. Mazzeo, Uwe D. Neue

Citations: 37 • 2002

Comprehensive automation of the solid phase extraction gas chromatographic mass spectrometric analysis (SPE-GC/MS) of opioids, cocaine, and metabolites from serum and other matrices

Oliver Lerch, Oliver Temme, Thomas Daldrup

Citations: 36 • 2014

Chromatographic separation of catecholic amino acids and catecholamines on immobilised phenylboronic acid

Christer Hansson, G Agrup, Hans Rorsman, Anna‐Maria Rosengren, Evald Rosengren

Citations: 36 • 1978

Turbulent flow and ternary column-switching on-line clean-up system for high-throughput quantification of risperidone and its main metabolite in plasma by LC–MS/MSApplication to a bioequivalence study

Constantinos Kousoulos, Yannis Dotsikas, Yannis L. Loukas

Citations: 32 • 2006

Multiplexed analysis of steroid hormones in saliva by LC-MS/MS with 2-hydrazinopyridine derivatization

Nirosa Nadarajah, Øyvind Skadberg, Jo Adaway, Cato Brede

Citations: 28 • 2017