Gry Kvalheim
Papers
2
Total Citations
286
H-Index
2
About
Gry Kvalheim is a leading figure in analytical biochemistry, renowned for pioneering high-throughput methods to quantify biomarkers of one-carbon metabolism. Her research focuses on developing robust mass spectrometry techniques to measure key metabolites, including methylmalonic acid (MMA), total homocysteine (tHcy), and related amino acids, which are critical for diagnosing cobalamin and folate deficiencies. Kvalheim’s landmark 2005 paper introduced an automated isotope-dilution GC-MS assay for simultaneous MMA and tHcy analysis in serum or plasma, a method that has garnered 153 citations for its clinical utility and precision. Building on this, her 2012 work established a high-throughput, low-volume HPLC-MS/MS approach for multianalyte quantification of one-carbon metabolism metabolites, earning 133 citations and enabling broader clinical and research applications. These contributions have significantly advanced the efficiency and accuracy of nutritional deficiency diagnostics, reducing sample volume and analysis time while maintaining sensitivity. Kvalheim’s methods are widely adopted in clinical laboratories and epidemiological studies, underscoring her impact on metabolic health research. Her work exemplifies how rigorous analytical innovation can translate into practical tools for improving patient care and understanding complex metabolic pathways.
Research Focus
Key Achievements
Top Papers
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