Zhi-Ying Guan
Papers
2
Total Citations
75
H-Index
2
About
Zhi-Ying Guan is a pioneering researcher in single-cell proteomics, a field that seeks to decode the protein landscape of individual cells—a critical frontier for understanding cellular heterogeneity in health and disease. Her major contribution is the development of the **Pick-up Single-Cell Proteomic Analysis (PiSPA)** workflow, a breakthrough that dramatically expands the depth of single-cell protein identification. While conventional shotgun proteomic methods plateau at roughly 1,000 proteins per cell, Guan’s PiSPA technique achieves quantification of up to **3,000 proteins per mammalian cell**, as demonstrated in her landmark 2024 paper (66 citations). This leap—tripling the detectable proteome—enables researchers to probe previously inaccessible biological complexity, from rare cell states to tumor microenvironments. Her work, first introduced in a 2022 study (9 citations), has rapidly garnered attention for its practical utility in cancer biology, where it can profile thousands of proteins from a single tumor cell. Guan’s innovation is not merely incremental; it provides a scalable, robust tool that pushes single-cell proteomics closer to routine application, empowering labs worldwide to ask deeper questions about cellular function and disease mechanisms.
Research Focus
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Top Papers
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