Qin‐Qin Xu
Papers
2
Total Citations
75
H-Index
2
About
Qin‐Qin Xu is a pioneering researcher in single-cell proteomics, whose work has dramatically expanded the limits of protein identification from individual cells. Her primary research focus is the development of ultra-sensitive mass spectrometry-based workflows to decode the proteome at the single-cell level. Xu’s major contribution is the invention of the pick-up single-cell proteomic analysis (PiSPA) workflow, a breakthrough technique that enables the quantification of up to 3,000 proteins from a single mammalian or tumor cell—tripling the typical identification depth of conventional shotgun methods. This advance directly addresses a critical bottleneck in single-cell biology, where insufficient protein coverage has limited practical applications. Her landmark 2024 paper on PiSPA has already garnered 66 citations, signaling its rapid adoption by the field. By pushing the frontier of single-cell proteomics, Xu is empowering researchers to explore cellular heterogeneity with unprecedented molecular resolution, opening new avenues in cancer biology, developmental biology, and precision medicine. Her work stands as a testament to the power of innovative sample handling and analytical chemistry in transforming our ability to study life’s fundamental units.
Research Focus
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Top Papers
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